胞苷尿苷鸟苷结合蛋白1/2,神经母细胞瘤细胞凋亡相关搁狈础结合蛋白抗体
规格：1尘驳/1尘濒
英文名： CUG-BP1/2
别名： CUG-BP1; CUG-BP12; Elav-type RNA-binding protein ETR3; Bruno-like protein 3; BRUNOL3; Cardiac elav type RNA binding protein; CELF-2; celf2; CELF2_HUMAN; CUG BP2; CUG triplet repeat RNA-binding protein
分子量： 54kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CUG-BP1
交叉反应：Human, Mouse, Rat, Pig, Cow, Rabbit, Xenopus laevis
细胞定位：细胞核 细胞浆
胞苷尿苷鸟苷结合蛋白1/2,神经母细胞瘤细胞凋亡相关搁狈础结合蛋白抗体产物介绍：background: Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Function: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not , skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle胞苷尿苷鸟苷结合蛋白1/2,神经母细胞瘤细胞凋亡相关搁狈础结合蛋白抗体 (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine胞苷尿苷鸟苷结合蛋白1/2,神经母细胞瘤细胞凋亡相关搁狈础结合蛋白抗体. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA (By similarity). Binds to an intronic RNA element responsible for the silencing of exon 21 splicing (By similarity). Binds to (CUG)n repeats. Subcellular Location: Nucleus. Cytoplasm. Accumulates in the cytoplasm after ionizing radiation (By similarity). Colocalizes with APOBEC1 and A1CF. RNA-binding activity is detected in both nuclear and cytoplasmic compartments. Tissue Specificity: Expressed in frontal cortex. Isoform 1 is expressed in brain and lung. Isoform 2 is expressed in heart, brain, placenta, lung, liver, kidney, skeletal muscle and pancreas. Isoform 4 is expressed in heart, lung, skeletal muscle, kidney and pancreas. Similarity: Belongs to the CELF/BRUNOL family. Contains 3 RRM (RNA recognition motif) domains. Gene ID: 10659 Database links: Entrez Gene: 10659 Human Entrez Gene: 14007 Mouse Entrez Gene: 100335150 Xenopus laevis Entrez Gene: 379280 Xenopus laevis Entrez Gene: 373117 Zebrafish Omim: 602538 Human SwissProt: Q7T2T1 Chicken SwissProt: O95319 Human SwissProt: Q9Z0H4 Mouse SwissProt: Q7ZXE2 Xenopus laevis SwissProt: Q6P0B1 Zebrafish Unigene: 309288 Human Unigene: 398543 Mouse Unigene: 1068 Xenopus laevis Unigene: 85486 Xenopus laevis Unigene: 77531 Zebrafish Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
胞苷尿苷鸟苷结合蛋白1/2,神经母细胞瘤细胞凋亡相关搁狈础结合蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 结合蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid