抑制素/肿瘤抑制因子抗体
规格：1尘驳/1尘濒
英文名： Prohibitin
别名： Mitochondrial Marker; PHB; prohibitin; PHB1; Prohibitin - Mitochondrial Marker; PHB_HUMAN.
分子量： 30kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Prohibit
交叉反应：Human, Mouse, Rat, Dog, Horse,
细胞定位：
抑制素/肿瘤抑制因子抗体产物介绍：background: This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Function: Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging. Subunit: Interacts with PHB2.抑制素/肿瘤抑制因子抗体 Interacts with STOML2. Subcellular Location: Mitochondrion inner membrane. Tissue Specificity: Widely expressed in different tissues. Similarity: Belongs to the prohibitin family. Gene ID: 5245 Database links: Entrez Gene: 5245 Human Entrez Gene: 18673 抑制素/肿瘤抑制因子抗体Mouse Entrez Gene: 25344 Rat Omim: 176705 Human SwissProt: P35232 Human SwissProt: P67778 Mouse SwissProt: P67779 Rat Unigene: 514303 Human Unigene: 263862 Mouse Unigene: 29754 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Prohibitin(phb)基因是一种有效的肿瘤抑制基因，广泛分布于不同种属的各种生物细胞中，它所编码的产物Prohibitin(PHB)蛋白结构保守，既存在于线粒体内膜上，发挥分子伴侣作用，也存在于细胞核内，具有负性转录调控作用，因而对细胞代谢、生长、分化、衰老以及凋亡等诸多方面发挥 着重要的调控作用，可能与某些肿瘤和退行性**的发生有关。
抑制素/肿瘤抑制因子抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 染色质和核信号 细胞凋亡 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid