颁顿339抗体
规格：1尘驳/1尘濒
英文名： Jagged1
别名： JAG1; AGS; AHD; AWS; CD339; HJ1; JAGL1;MGC104644; Ser 1; CD 339; CD339; CD339 antigen; Headturner; Htu; Jag 1; Jagged-1; Jagged 1; Jagged 1 (Alagille syndrome); JAGL1; Ser-1; Ser1; Serrate-1; Slalom.
分子量： 134kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CD339
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
颁顿339抗体产物介绍：background: The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq]. Function: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro). Subcellular Location: Membrane. Tissue Specificity: Widely expressed in 颁顿339抗体 and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells. DISEASE: Defects in JAG1 are the cause of Alagille syndrome type 1 (ALGS1) [MIM:118450]. Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems. Defects in JAG1 are a cause of tetralogy 颁顿339抗体of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. Surgical correction is emergent. Similarity: Contains 1 DSL domain. Contains 15 EGF-like domains. Gene ID: 182 Database links: Entrez Gene: 182 Human Entrez Gene: 16449 Mouse Entrez Gene: 29146 Rat Omim: 601920 Human SwissProt: P78504 Human SwissProt: Q9QXX0 Mouse SwissProt: Q63722 Rat Unigene: 224012 Human Unigene: 22398 Mouse Unigene: 88804 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
颁顿339抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 发育生物学 神经生物学 信号转导 干细胞 细胞膜受体 细胞表面分子 自然杀伤细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid