顿笔贬3蛋白抗体
规格：1尘驳/1尘濒
英文名： DPH3
别名： CSL-type zinc finger-containing protein 2; Deafness locus putative guanine nucleotide exchange factor interacting protein 1; DelGEF-interacting protein 1; DELGIP; DelGIP1; DESR1; Diphtheria toxin and
分子量： 9.2kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DPH3
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核 细胞浆
顿笔贬3蛋白抗体产物介绍：background: This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009] Function: Essential for the first step in the顿笔贬3蛋白抗体 synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A. Down-regulation increases extracellular release of proteoglycans, indicating a possible role in the secretion process. Stimulates binding of GNEFR to SEC5. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity:顿笔贬3蛋白抗体 Widely expressed with highest levels in small intestine, spleen, thymus, heart, liver and lung. Similarity: Belongs to the DPH3 family. Contains 1 DPH-type zinc finger. Gene ID: 285381 Database links: Entrez Gene: 285381 Human Omim: 608959 Human SwissProt: Q96FX2 Human Unigene: 388087 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
顿笔贬3蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 **及病毒
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid