顿翱颁2叠蛋白抗体
规格：1尘驳/1尘濒
英文名： DOC2B
别名： Doc2 beta; Doc2-beta; Doc2b; DOC2B_HUMAN; DOC2BL; Double C2 like domain containing protein beta; Double C2 like domains beta; Double C2 like domains beta like; Double C2-like domain-containing protein
分子量： 46kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DOC2B
交叉反应：Human, Mouse, Rat, Chicken, Cow, Horse, Sheep,
细胞定位：细胞浆 细胞膜
顿翱颁2叠蛋白抗体产物介绍：background: There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to be involved in Ca(2+)-dependent intracellular vesicle trafficking in various types of cells. [provided by RefSeq, Jul 2008] Function: Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage 顿翱颁2叠蛋白抗体of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity). Subcellular Location:顿翱颁2叠蛋白抗体 Cytoplasm. Cytoplasmic granule. Cell membrane. Translocates to the plasma membrane in a calcium-dependent manner. Tissue Specificity: Widely expressed with highest levels in brain and kidney. Expressed in pancreatic islet cells (at protein level). Similarity: Contains 2 C2 domains. Gene ID: 8447 Database links: Entrez Gene: 8447 Human Entrez Gene: 13447 Mouse Entrez Gene: 81820 Rat Omim: 604568 Human SwissProt: Q14184 Human SwissProt: P70169 Mouse SwissProt: P70610 Rat Unigene: 551705 Human Unigene: 5137 Mouse Unigene: 10689 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
顿翱颁2叠蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 转运蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid