肝癌缺失基因1/2抗体
规格：1尘驳/1尘濒
英文名： DLC1 + DLC2
别名： ARHGAP 7; ARHGAP7; Deleted in liver cancer 1; Deleted in liver cancer 1 protein; DLC 1; Dlc-1; DLC1; FLJ21120; HP; HP protein; KIAA1723; p122 RhoGAP; RHG07_HUMAN; Rho GTPase activating protein 7; Rho
分子量： 171/122kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Rho GTPa
交叉反应：Human, Mouse, Rat, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜 线粒体
肝癌缺失基因1/2抗体产物介绍：background: This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010] Function: Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Subunit: Interacts with EF1A1, facilitates EF1A1 distribution to the membrane periphery and ruffles upon growth 肝癌缺失基因1/2抗体factor stimulation and suppresses cell migration. Subcellular Location: Cytoplasm. Cell junction, focal adhesion. Membrane; Peripheral membrane protein. Note=Colocalizes with EF1A1 at actin-rich regions in the cell periphery. Tissue Specificity: Highest level of expression in the spleen, with rather lower levels in prostate, testis, ovary, small intestine and colon, but none in the thymus. Post-translational modifications: Phosphorylation at Ser-88 appears to control the dimer-monomer transition. According to PubMed:15193260, it is phosphorylated at Ser-88 by PAK1, however, according to PubMed:18650427, the DYNLL1 dimer is not accessible for PAK1 and the phosphorylation could not be demonstrated in vitro. Similarity:肝癌缺失基因1/2抗体 Contains 1 Rho-GAP domain. Contains 1 SAM (sterile alpha motif) domain. Contains 1 START domain. Gene ID: 10395 90627 Database links: Entrez Gene: 10395 Human Entrez Gene: 90627 Human Entrez Gene: 50768 Mouse Omim: 604258 Human Omim: 609866 Human SwissProt: Q96QB1 Human SwissProt: Q9Y3M8 Human SwissProt: Q9R0Z9 Mouse Unigene: 134296 Human Unigene: 210875 Mouse SwissProt: P63170 Rat Unigene: 5120 Human Unigene: 256858 Mouse Unigene: 35769 Rat Unigene: 507704 Human Unigene: 721224 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肝癌缺失基因1/2抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 线粒体 表观遗传学 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid