鳞状细胞癌相关蛋白抗体
规格：1尘驳/1尘濒
英文名： DCUN1D1
别名： DCN1 defective in cullin neddylation 1 domain containing 1; DCN1 like protein 1; DCNL1; DCNL1_HUMAN; DCUN1 domain containing protein 1; DCUN1L1; Defective in cullin neddylation protein 1 like protein
分子量： 30kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DCUN1D1
交叉反应：Human, Mouse, Chicken, Cow, Horse,
细胞定位：
鳞状细胞癌相关蛋白抗体产物介绍：background: DCUN1D1 (DCUN1 domain-containing protein 1) contains a DUF298 domain and a UBA-like ubiquitin. Forms part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene鳞状细胞癌相关蛋白抗体 facilitating malignant transformation and carcinogenic progression. Defects in DCUN1D1 may be a cause of squamous cell carcinomas. Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carcinoma of the oral tongue. Not overexpressed in aggressive adrenocortical carcinomas. Gene ID: 54165 Database links: Entrez Gene: 54165鳞状细胞癌相关蛋白抗体 Human Entrez Gene: 424963 Chicken Entrez Gene: 539869 Cow Entrez Gene: 114893 Mouse Entrez Gene: 327232 Zebrafish Omim: 605905 Human SwissProt: Q5ZKU1 Chicken SwissProt: Q96GG9 Human SwissProt: Q9QZ73 Mouse Unigene: 104613 Human Unigene: 374810 Mouse Unigene: 379305 Mouse Unigene: 474495 Mouse Unigene: 113807 Zebrafish Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
鳞状细胞癌相关蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 肿瘤细胞生物标志物 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid