羰基还原酶2抗体
规格：1尘驳/1尘濒
英文名： DCXR
别名： Carbonyl reductase 2; Carbonyl reductase II; DCR; Dcxr; DCXR_HUMAN; Dicarbonyl L xylulose reductase; Dicarbonyl/ L xylulose reductase; Dicarbonyl/L-xylulose reductase; HCR2; HCRII; Human carbonyl redu
分子量： 26kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DCXR
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
羰基还原酶2抗体产物介绍：background: DCXR is a 244 amino acid member of the short-chain dehydrogenases/reductases family. This peripheral membrane protein catalyzes NADPH-dependent reduction of mulitple sugars, including L-xylulose, to the osmolyte xylitol. Producing xylitol in the renal tubules can prevent osmotic stress. L-xylulose reductase functions as a homotetramer and is expressed highly in kidney, liver and epididymis. Essential pentosuria is the result of a partial deficiency of L-xylulose reductase. Red blood cells of normal individuals contain two L-xylulose reductases: a major and a minor isozyme. Red cells from patients with pentosuria contain only one isozyme. Due to its role in the uronate cycle of glucose metabolism, L-xylulose reductase has been implicated in the management of the long term complications of diabetes. Function: Catalyzes羰基还原酶2抗体 the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. Subcellular Location: Membrane. Probably recruited to membranes via an interaction with phosphatidylinositol. Tissue Specificity: Highly expressed in kidney, liver and epididymis. In the epididymis, it is 羰基还原酶2抗体mainly expressed in the proximal and distal sections of the corpus region. Weakly or not expressed in brain, lung, heart, spleen and testis. DISEASE: Note=The enzyme defect in pentosuria has been shown to involve L-xylulose reductase. Essential pentosuria is an inborn error of metabolism characterized by the excessive urinary excretion of the pentose L-xylulose. Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. Gene ID: 51181 Database links: Entrez Gene: 51181 Human Entrez Gene: 526937 Cow Entrez Gene: 67880 Mouse Entrez Gene: 171408 Rat Omim: 608347 Human SwissProt: Q1JP75 Cow SwissProt: Q7Z4W1 Human SwissProt: Q91X52 Mouse SwissProt: Q920P0 Rat Unigene: 9857 Human Unigene: 231091 Mouse Unigene: 177518 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
羰基还原酶2抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid