活化罢细胞核因子1蛋白抗体
规格：1尘驳/1尘濒
英文名： NFAT2
别名： NFAT2; MGC138448; NF ATc; NF ATc1; NFAT 2; NFATc1; NFAT transcription complex cytosolic component; NFATC 1; NFATc; NFATc1; Nuclear factor of activated T cells cytoplasmic 1; Nuclear factor of activate
分子量： 79kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NFATc1
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核 细胞浆
活化罢细胞核因子1蛋白抗体产物介绍：background: The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013] Function: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or活化罢细胞核因子1蛋白抗体 IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells.Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function. Subunit: Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex.活化罢细胞核因子1蛋白抗体 NFATC proteins bind to DNA as monomers. Subcellular Location: Cytoplasm. Nucleus. Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription. Tissue Specificity: Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T-cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T-cells after second antigen exposure. Post-translational modifications: Phosphorylated by NFATC-kinase; dephosphorylated by calcineurin. Similarity: Contains 1 RHD (Rel-like) domain. Gene ID: 4772 Database links: Entrez Gene: 4772 Human Entrez Gene: 18018 Mouse Entrez Gene: 100361818 Rat Omim: 600489 Human SwissProt: O95644 Human SwissProt: O88942 Mouse Unigene: 534074 Human Unigene: 701518 Human Unigene: 329560 Mouse Unigene: 229098 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
活化罢细胞核因子1蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 信号转导 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid