细胞质贵惭搁1相关蛋白抗体
规格：1尘驳/1尘濒
英文名： CYFIP1
别名： CY; CYFIP 1; CYFIP1; CYFP1_HUMAN; Cytoplasmic FMR1 interacting protein 1; Cytoplasmic FMR1-interacting protein 1; FLJ45151; KIAA0068; p140sra 1; p140sra-1; P140SRA1; Selective hybridizing clone; SHYC;
分子量： 145kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CYFIP1
交叉反应：Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep,
细胞定位：细胞浆
细胞质贵惭搁1相关蛋白抗体产物介绍：background: CYFIP1 are cytoplasmic proteins belonging to the CYFIP family. Both proteins bind GTP-bound Rac 1 to release FRM1 in its active state, which is thought to regulate mRNA translation of neural cytoskeletal proteins. A loss of CYFIP1 and CYFIP2 leads to mutant neurons with defective axonal growth and motor function. Also designated specifically Rac1-associated protein 1 (sra-1) or p140sra-1, CYFIP1 contains 1,253 amino acids and is a component of the WAVE2 complex. CYFIP1 is encoded by a gene that maps to human chromosome 15q11.2 and exists as three alternatively spliced isoforms. CYFIP2, also known as p53-inducible protein 121, contains 细胞质贵惭搁1相关蛋白抗体1,278 amino acids and plays a role in p53-dependent apoptosis. Existing as two alternatively spliced isoforms, CYFIP2 is a component of the WAVE1 complex and is encoded by a gene located on human chromosome 5q33.3. Function: Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA. Regulator细胞质贵惭搁1相关蛋白抗体 of epithelial morphogenesis. May act as an invasion suppressor in cancers. Subcellular Location: Cytoplasm > perinuclear region. Cell projection > lamellipodium. Cell projection > ruffle. Cell junction > synapse > synaptosome. Highly expressed in the perinuclear region. Enriched in synaptosomes, membrane ruffles and at the tips of lamellipodia. Similarity: Belongs to the CYFIP family. Gene ID: 23191 Database links: Entrez Gene: 23191 Human Entrez Gene: 20430 Mouse Entrez Gene: 308666 Rat Entrez Gene: 336613 Zebrafish Omim: 606322 Human SwissProt: Q7L576 Human SwissProt: Q7TMB8 Mouse SwissProt: Q90YM8 Zebrafish Unigene: 26704 Human Unigene: 333893 Mouse Unigene: 37249 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞质贵惭搁1相关蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid