7号染色体开放阅读框68抗体
规格：1尘驳/1尘濒
英文名： CTC1
别名： CTC1; C17orf68; Conserved telomere maintenance component 1; CST complex subunit CTC1; CTC1; CTC1_HUMAN; HBV DNAPTP1-transactivated protein B.
分子量： 135kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CTC1/C17
交叉反应：Human, Mouse, Rat, Rabbit,
细胞定位：细胞核
7号染色体开放阅读框68抗体产物介绍：background: This gene encodes a component of the CST complex. This complex plays an essential role in protecting telomeres from degradation. This protein also forms a heterodimer with the CST complex subunit STN1 to form the enzyme alpha accessory factor. This enzyme regulates DNA replication. Mutations in this gene are the cause of cerebroretinal microangiopathy with calcifications and cysts. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012] Function: Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST7号染色体开放阅读框68抗体 complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites. Subcellular Location: Nucleus. Chromosome > telomere. A transmembrane region is predicted by sequence analysis tools (ESKW, MEMSAT and Phobius); however, given the telomeric localization of the protein, the relevance of the transmembrane region is unsure in vivo. 7号染色体开放阅读框68抗体DISEASE: Cerebroretinal microangiopathy with calcifications and cysts Similarity: Belongs to the CTC1 family. Gene ID: 80169 Database links: Entrez Gene: 80169 Human Omim: 613129 Human SwissProt: Q2NKJ3 Human Unigene: 156055 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
7号染色体开放阅读框68抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid