剪切及多聚腺苷酸化特异因子蛋白2抗体
规格：1尘驳/1尘濒
英文名： CPSF2
别名： Cleavage and polyadenylation specific factor 2; Cleavage and polyadenylation specificity factor 100 kDa subunit; Cleavage and polyadenylation specificity factor subunit 2; CPSF 100 kDa subunit; CPSF 2
分子量： 88kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CPSF2
交叉反应：Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit,
细胞定位：细胞核
剪切及多聚腺苷酸化特异因子蛋白2抗体产物介绍：background: CPSF contains four subunits and localizes to the nucleoplasm where it recognizes the AAUAAA signal in pre-mRNA and interacts with other proteins to facilitate RNA cleavage and poly(A) synthesis (1,4,5). The human CPSF2 gene maps to chromosome 14q32.12 and encodes the second largest subunit of cleavage and polyadenylation specificity factor. U1 snRNP-A protein (U1A) interacts with and affects the activity of CPSF by stabilizing the interaction of CPSF with the AAUAAA-containing RNAs to剪切及多聚腺苷酸化特异因子蛋白2抗体 increase the efficiency of polyadenylation . Function: CPSF2 belongs to the RNA-metabolizing metallo-beta-lactamase-like family, CPSF2/YSH1 subfamily. It is a component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3 prime-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other 剪切及多聚腺苷酸化特异因子蛋白2抗体factors to bring about cleavage and poly(A) addition. A poly(A) tail is added to eukaryotic mRNA precursors after tightly coupled cleavage and polyadenylation reactions at their 3-prime ends. Subcellular Location: Nuclear. Gene ID: 53981 Database links: Entrez Gene: 53981 Human Entrez Gene: 51786 Mouse Entrez Gene: 299256 Rat Omim: 606028 Human SwissProt: Q9P2I0 Human SwissProt: O35218 Mouse SwissProt: D3Z9E6 Rat Unigene: 657632 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
剪切及多聚腺苷酸化特异因子蛋白2抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：染色质和核信号 细胞分化 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid