血清应答因子抗体
规格：1尘驳/1尘濒
英文名： SRF
别名： c fos serum response element binding factor; Serum Response Factor SRF; c fos serum response element binding transcription factor; ELK3; ERP; MCM 1; MCM-1; MCM1; OTTHUMP00000039820; SAP2; Serum respon
分子量： 56kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SRF
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow,
细胞定位：细胞核
血清应答因子抗体产物介绍：background: This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs).血清应答因子抗体 [provided by RefSeq, Jul 2008]. Function: SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation. Subunit: Binds DNA as a multimer, probably a dimer. Interacts with MLLT7/FOXO4, NKX3A and SSRP1. Interacts with ARID2 and SRFBP1. Forms complexes with ARID2, MYOCD, NKX2-5 and SRFBP1. Forms a nuclear ternary complex with MKL1 and SCAI. Subcellular Location: 血清应答因子抗体Nucleus. Post-translational modifications: Phosphorylated by PRKDC. Similarity: Contains 1 MADS-box domain. Gene ID: 6722 Database links: Entrez Gene: 6722 Human Entrez Gene: 20807 Mouse Entrez Gene: 501099 Rat Omim: 600589 Human SwissProt: P11831 Human SwissProt: Q9JM73 Mouse Unigene: 520140 Human Unigene: 45044 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 转录调节因子（Transcriptin Regulators） 血清应答因子(SRF)是一种转录因子蛋白，可以结合启动子DNA序列中的血清应答元件(SRE)，调节一系列基因的表达，包括即刻早期基因的表达，如c-fos、fosB、junB、egr-1、egr-2，以及神经元基因nurr1、肌肉基因如肌动蛋白、肌球蛋白基因等.
血清应答因子抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 干细胞 细胞凋亡 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid