颁翱搁贰厂罢蛋白抗体
规格：1尘驳/1尘濒
英文名： COREST
别名： COREST; KIAA0071; Protein CoREST; RCOR; RCOR1; RCOR1_HUMAN; REST corepressor 1.
分子量： 53kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human COREST
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞核
颁翱搁贰厂罢蛋白抗体产物介绍：background: This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011] Function: Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by颁翱搁贰厂罢蛋白抗体 deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Subcellular Location: Nucleus. Upon infection by HSV-1, it is partially translocated into the颁翱搁贰厂罢蛋白抗体 cytoplasm in an HSV-1-dependent manner. Tissue Specificity: Ubiquitously expressed. Post-translational modifications: Phosphorylated by HSV-1 protein kinases in case of infection. Similarity: Belongs to the CoREST family. Contains 1 ELM2 domain. Contains 2 SANT domains. Gene ID: 23186 Database links: Entrez Gene: 23186 Human Entrez Gene: 217864 Mouse Omim: 607675 Human SwissProt: Q9UKL0 Human SwissProt: Q8CFE3 Mouse Unigene: 510521 Human Unigene: 23808 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
颁翱搁贰厂罢蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 染色质和核信号 神经生物学 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid