雄烷受体颁础搁抗体
规格：1尘驳/1尘濒
英文名： Constitutive androstane receptor
别名： CAR; CAR BETA; CAR1; CARA; Constitutive activator of retinoid response; Constitutive active response; Constitutive androstane receptor; MGC97144; NR1I3; NR1I3_HUMAN; Nuclear receptor subfamily 1 group
分子量： 45kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Constitu
交叉反应：Human, Chimpanzee,
细胞定位：细胞核 细胞浆 细胞膜
雄烷受体颁础搁抗体产物介绍：background: This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include雄烷受体颁础搁抗体 bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. Subcellular Location: Nucleus. Cytoplasm. Cytoplasm; cytoskeleton.雄烷受体颁础搁抗体 Recruited to the cytoplasm by DNAJC7. Tissue Specificity: Predominantly expressed in liver. Post-translational modifications: Phosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation. Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. Gene ID: 9970 Database links: Entrez Gene: 9970 Human Entrez Gene: 12355 Mouse Entrez Gene: 65035 Rat Omim: 603881 Human SwissProt: Q14994 Human SwissProt: O35627 Mouse SwissProt: Q9QUS1 Rat Unigene: 349642 Human Unigene: 486506 Mouse Unigene: 163229 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
雄烷受体颁础搁抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid