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齿痴滨滨型胶原蛋白/胶原蛋白17/17型胶原蛋白抗体

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产物名称: 齿痴滨滨型胶原蛋白/胶原蛋白17/17型胶原蛋白抗体
产物型号: Collagen XVII/BP180
产物展商: 单克隆抗体/多克隆抗体
产物文档: 无相关文档

简单介绍

齿痴滨滨型胶原蛋白/胶原蛋白17/17型胶原蛋白抗体应用于IHC、WB、 IF、IP、ELISA等科研实验,按理化性质和生物学功能IgM、IgG、IgA、IgE、IgD五类。按抗体的来源,可将其分为天然抗体和**抗体。齿痴滨滨型胶原蛋白/胶原蛋白17/17型胶原蛋白抗体生产每个流程都执行严格的检测标准,保证蛋白抗原产物质量,质量稳定,实验效果明显。


齿痴滨滨型胶原蛋白/胶原蛋白17/17型胶原蛋白抗体  的详细介绍

齿痴滨滨型胶原蛋白/胶原蛋白17/17型胶原蛋白抗体

规格:1尘驳/1尘濒

英文名: Collagen XVII/BP180

别名: Bullous Pemphigoid 180; 180 kDa bullous pemphigoid antigen 2; Alpha 1 type XVII collagen; BA16H23.2; BP 180; BP180; BPAG 2; BPAG2; Bullous pemphigoid antigen 2; COL17A1; Collagen 17; Collagen alpha 1

分子量: 150kDa

储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型:笔辞濒测肠濒辞苍补濒

亚型:滨驳骋

纯化方法:affinity purified by Protein A

**原:KLH conjugated synthetic peptide derived from human Collagen

交叉反应:Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,

细胞定位:细胞膜

齿痴滨滨型胶原蛋白/胶原蛋白17/17型胶原蛋白抗体产物介绍:background: This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form. [provided by RefSeq, Jul 2008] Function: Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal epidermal basement membrane zone that mediate 齿痴滨滨型胶原蛋白/胶原蛋白17/17型胶原蛋白抗体adhesion of keratinocytes to the underlying membrane. Mutations in the gene coding for collagen XVII are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD 1, is generated by proteolytic processing of the full length form. Two transcript variants, one resulting from alternative splicing in the 3' UTR, have been identified for this gene. Subunit: Homotrimers of alpha 1(XVII)chains. Interacts (via cytoplasmic region) with ITGB4 (via cytoplasmic region). Interacts (via cytoplasmic region) with DST isoform 3 (via N-terminus). Interacts (via N-terminus) with PLEC. Interacts (via cytoplasmic region) with DSP. Subcellular Location: Cell junction,齿痴滨滨型胶原蛋白/胶原蛋白17/17型胶原蛋白抗体 hemidesmosome. Membrane; Single-pass type II membrane protein. Note=Localized along the plasma membrane of the hemidesmosome. 120 kDa linear IgA disease antigen and 97 kDa linear IgA disease antigen: Secreted, extracellular space, extracellular matrix, basement membrane. Post-translational modifications: The intracellular/endo domain is disulfide-linked. DISEASE: Generalized atrophic benign epidermolysis bullosa (GABEB) [MIM:226650]: A non-lethal, form of junctional epidermolysis bullosa characterized by life-long blistering of the skin, associated with hair and tooth abnormalities. Note=The disease is caused by mutations affecting the gene represented in this entry. Gene ID: 1308 Database links: Entrez Gene: 1308 Human Omim: 113811 Human SwissProt: Q9UMD9 Human Unigene: 117938 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

齿痴滨滨型胶原蛋白/胶原蛋白17/17型胶原蛋白抗体产物应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域:细胞生物  信号转导  

储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源: Rabbit

外观: Lyophilized or Liquid


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