细胞因子诱导蛋白29办顿补抗体
规格：1尘驳/1尘濒
英文名： CIP29
别名： Cytokine induced protein of 29 kDa; Cytokine-induced protein of 29 kDa; HCC 1; HCC1; HSPC316; Nuclear protein Hcc 1; Nuclear protein Hcc-1; Proliferation associated cytokine inducible protein CIP29; P
分子量： 24kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CIP29
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse,
细胞定位：细胞核
细胞因子诱导蛋白29办顿补抗体产物介绍：background: CIP29 is a 210 amino acid nuclear protein whose expression is upregulated by erythropoietin. Induction of CIP2 expression is associated with cell cycle progression and apoptosis. This transcription factor binds both single stranded (ss) and double stranded (ds) DNA, though it has higher affinity for ssDNA. CIP29 is expressed at low levels in pancreas, spleen, testis, liver, kidney, heart and thymus, and is found to be expressed at higher levels in pancreatic adenocarcinoma and hepatocellular carcinoma. 细胞因子诱导蛋白29办顿补抗体A translocation t(11;12)(q23;q13) in acute myelomonocytic leukemia results in the coding region of CIP29 gene fused to exon 9 of the MLL gene, which encodes for a protein with the N-terminal SAP domain and two C-terminal nuclear localization signals of CIP29 and N-termial AT hooks and central DNA methyltransferase homology region of MLL. Function: Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding细胞因子诱导蛋白29办顿补抗体 activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Subcellular Location: Nucleus. Tissue Specificity: Low expression in spleen, liver, pancreas, testis, thymus, heart, and kidney. Increased levels are seen in hepatocellular carcinoma and pancreatic adenocarcinoma. Similarity: Contains 1 SAP domain. Gene ID: 84324 Database links: Entrez Gene: 84324 Human Entrez Gene: 732539 Cow Entrez Gene: 66118 Mouse Entrez Gene: 362819 Rat Omim: 610049 Human SwissProt: P82979 Human SwissProt: Q9D1J3 Mouse SwissProt: Q498U4 Rat Unigene: 505676 Human Unigene: 351579 Mouse Unigene: 1506 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞因子诱导蛋白29办顿补抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 细胞凋亡 细胞周期蛋白 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid