软骨中间层蛋白颁滨尝笔抗体
规格：1尘驳/1尘濒
英文名： CILP
别名： Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2; cartilage intermediate layer protein; cartilage intermediate layer protein, nucleotide pyrophosphohydrolase; Carti
分子量： 132kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CILP
交叉反应：Human, Mouse, Rat, Cow, Horse, Sheep,
细胞定位：细胞浆
软骨中间层蛋白颁滨尝笔抗体产物介绍：background: Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease. [provided by RefSeq, Sep 2010] Function: Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage. Subcellular Location: Secreted >软骨中间层蛋白颁滨尝笔抗体 extracellular space > extracellular matrix. Tissue Specificity: Specifically expressed in cartilage. Localizes in the intermediates layer of articular cartilage but neither in the superficial nor in the deepest regions. Specifically and highly expressed in intervertebral disk tissue. Expression increases with aging in hip articular cartilage. Overexpressed in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease (CPPD). Expression in intervertebral disk tissue from individuals with lumbar disk disease increases as disk degeneration progresses. Post-translational modifications: Cleaved into 2 chains possibly by a furin-like protease upon or preceding secretion. DISEASE: Defects in 软骨中间层蛋白颁滨尝笔抗体CILP are a cause of susceptibility to intervertebral disk disease (IDD) [MIM:603932]. A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. Note=Susceptibility to intervertebral disk disease, is conferred by variant p.Ile395Thr (PubMed:15864306). Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 TSP type-1 domain. Gene ID: 8483 Database links: Entrez Gene: 8483 Human Entrez Gene: 214425 Mouse Entrez Gene: 397672 Pig omim: 603489 Human SwissProt: O75339 Human SwissProt: Q66K08 Mouse Unigene: 442180 Human Unigene: 138455 Mouse Unigene: 14477 Pig Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
软骨中间层蛋白颁滨尝笔抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid