染色质修饰蛋白颁贬惭笔6抗体
规格：1尘驳/1尘濒
英文名： CHMP6
别名： CHMP6_HUMAN; Charged multivesicular body protein 6; Chromatin-modifying protein 6; Vacuolar protein sorting-associated protein 20; Vps20; hVps20.
分子量： 23kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CHMP6
交叉反应：Human, Mouse, Rat, Cow,
细胞定位：
染色质修饰蛋白颁贬惭笔6抗体产物介绍：background: The charged multivesicular body proteins, commonly designated CHMPs, belong to the vacuolar sorting protein family and function as chromatin-modifying proteins. CHMP1-6 are all components of ESCRT (endosomal sorting complex required for transport) I, II or III complexes. These complexes are crucial for sorting endosomal articles into multivesicular bodies (MVBs), as well as required for the formation of these bodies. During HIV-1 infection, the virus uses the ESCRT-III complex to mediate budding and exocytosis of viral proteins. CHMP6, also known as VPS20, interacts with CHMP4 of the ESCRT-III complex. CHMP6 also interacts with SNF8, VPS25 and VPS36 of the ESCRT-II complex, where it regulates cargo sorting by acting as an acceptor for ESCRT-II on endosome membranes Function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically 染色质修饰蛋白颁贬惭笔6抗体equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes. Subunit: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are染色质修饰蛋白颁贬惭笔6抗体 thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentally. Interacts with VPS4A; the interaction is direct. Interacts with VPS4B; the interaction is direct. Interacts with CHMP4A, CHMP4B and CHMP4C. Interacts with SNF8, VPS25 and VPS36. Subcellular Location: Endomembrane system. Endosome membrane. Late endosome membrane. Localizes to endosomal membranes. Tissue Specificity: Ubiquitously expressed. Similarity: Belongs to the SNF7 family. Gene ID: 79643 Database links: Entrez Gene: 79643 Human Omim: 610901 Human SwissProt: Q96FZ7 Human Unigene: 514560 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
染色质修饰蛋白颁贬惭笔6抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid