自噬微管相关蛋白轻链3抗体
规格：1尘驳/1尘濒
英文名： LC3A/B + LC3B + LC3C
别名： LC3; MAP1A; LC3 alpha; MAP1LC3A; MAP1a + MAP1b; microtubule-associated protein 1 light chain 3; Autophagy LC3; Microtubule-associated proteins 1A/1B light chain 3A; MAPLC3; MAP-LC3; Microtubule-associ
分子量： 12-14kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LC3A/B +
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆
自噬微管相关蛋白轻链3抗体产物介绍：background: MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. [provided by RefSeq, Feb 2012]. Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8 (He et al.,自噬微管相关蛋白轻链3抗体 2003 [PubMed 12740394]).[supplied by OMIM, Nov 2010]. Function: Probably involved in formation of autophagosomal vacuoles (autophagosomes). Subunit: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. Interacts with SQSTM1. Interacts with TP53INP1 and TP53INP2. Subcellular Location: Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome. Note=LC3-II binds to the autophagic membranes. Tissue Specificity: Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes. Post-translational modifications: The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and 自噬微管相关蛋白轻链3抗体conjugated to phospholipid to form the membrane-bound form, LC3-II. Similarity: Detects a band of approximately 16 kDa (predicted molecular weight: 14 kDa). Gene ID: 4130 440738 81631 Database links: Entrez Gene: 4130 Human Entrez Gene: 440738 Human Entrez Gene: 81631 Human Entrez Gene: 17754 Mouse Entrez Gene: 67443 Mouse Entrez Gene: 25152 Rat Entrez Gene: 64862 Rat Omim: 600178 Human Omim: 609605 Human SwissProt: P78559 Human SwissProt: Q9BXW4 Human SwissProt: Q9QYR6 Mouse SwissProt: P34926 Rat Unigene: 194301 Human Unigene: 619338 Human Unigene: 534971 Human Unigene: 36501 Mouse Unigene: 11402 Rat Unigene: 41412 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
自噬微管相关蛋白轻链3抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 神经生物学 信号转导 细胞凋亡 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid