结蛋白样蛋白颁骋狈尝1抗体
规格：1尘驳/1尘濒
英文名： CGNL1
别名： Cgnl1; CGNL1_HUMAN; Cingulin like 1; Cingulin-like protein 1; FLJ14957; JACOP; Junction-associated coiled-coil protein; KIAA1749; MGC138254; Paracingulin.
分子量： 149kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CGNL1
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
细胞定位：
结蛋白样蛋白颁骋狈尝1抗体产物介绍：background: This gene encodes a member of the cingulin family. The encoded protein localizes to both adherens and tight cell-cell junctions and mediates junction assembly and maintenance by regulating the activity of the small GTPases RhoA and Rac1. Heterozygous chromosomal rearrangements resulting in association of the promoter for this gene with the aromatase gene are a cause of aromatase excess syndrome. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011] Function: May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. 结蛋白样蛋白颁骋狈尝1抗体Subcellular Location: Cell junction > tight junction. Localizes to the apical junction complex composed of tight and adherens junctions. Tissue Specificity: Smooth muscle, spleen, testis, fetal brain, amygdala, corpus callosum, cerebellum, thalamus and subthalamic nucleus of brain. DISEASE: A chromosomal aberration involving CGNL1 is a cause of aromatase excess syndrome [MIM:139300]. This is characterized by an estrogen excess due to an increased aromatase activity. An inversion on inv(15)(q21.2;q21.3) moves the promoter of the CGNL1 gene into 结蛋白样蛋白颁骋狈尝1抗体a 5-prime position in relation to the aromatase coding region. Similarity: Belongs to the cingulin family. Gene ID: 84952 Database links: Entrez Gene: 84952 Human Omim: 607856 Human SwissProt: Q0VF96 Human Unigene: 148989 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
结蛋白样蛋白颁骋狈尝1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 转录调节因子 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid