中心体蛋白95抗体
规格：1尘驳/1尘濒
英文名： CEP95
别名： CCDC45; Centrosomal protein 95kDa; Centrosomal protein of 95 kDa; Cep95; CEP95_HUMAN; Coiled coil domain containing 45; Coiled-coil domain-containing protein 45.
分子量： 95kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CEP95
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆
中心体蛋白95抗体产物介绍：background: The coiled-coil domain is a structural motif found in proteins that are involved in a diverse array of biological functions such as the regulation of gene expression, cell division, membrane fusion and drug extrusion and delivery. CCDC45 (coiled-coil domain containing 45) is a 821 amino acid protein encoded by a gene that maps to human chromosome 17q23.3. Chromosome 17 comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through中心体蛋白95抗体 DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Subcellular Location: Cytoplasm; cytoskeleton; centrosome. 中心体蛋白95抗体Cytoplasm ; cytoskeleton; spindle pole. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Gene ID: 90799 Database links: Entrez Gene: 90799 Human Entrez Gene: 320162 Mouse Entrez Gene: 287766 Rat SwissProt: Q96GE4 Human SwissProt: Q8BVV7 Mouse SwissProt: Q5XI03 Rat Unigene: 569713 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
中心体蛋白95抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 细胞分化 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid