整合素样金属蛋白酶与凝血酶1型-12抗体
规格：1尘驳/1尘濒
英文名： ADAMTS12
别名： A disintegrin and metalloproteinase with thrombospondin motifs 12; A disintegrin like and metalloprotease with thrombospondin type 1 motif 12; ADAM metallopeptidase with thrombospondin type 1 motif 12
分子量： 175kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ADAMTS12
交叉反应：Human, Mouse, Rat,
细胞定位：细胞外基质 分泌型蛋白
整合素样金属蛋白酶与凝血酶1型-12抗体产物介绍：background: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq]. Function: Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. Subunit: Interacts with COMP. Subcellular Location: Secreted, 整合素样金属蛋白酶与凝血酶1型-12抗体extracellular space, extracellular matrix. Tissue Specificity: Expressed in skeletal muscle and fat. Detected at significant levels in fetal lung. Widely expressed in gastric carcinomas and in cancer cells of diverse origin. Post-translational modifications: The precursor is cleaved by a furin endopeptidase. Subjected to an intracellular maturation process yielding a 120 kDa N-terminal fragment containing the metalloproteinase, disintegrin, one TSP type-1 and the Cys-rich domains and a 83 kDa C-terminal fragment containing the spacer 2 and four TSP type-1 domains. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be整合素样金属蛋白酶与凝血酶1型-12抗体 further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion. Similarity: Contains 1 disintegrin domain. Contains 1 peptidase M12B domain. Contains 1 PLAC domain. Contains 8 TSP type-1 domains. Gene ID: 81792 Database links: Entrez Gene: 81792 Human Entrez Gene: 239337 Mouse Omim: 606184 Human SwissProt: P58397 Human SwissProt: Q3UM66 Mouse SwissProt: Q3UXR3 Mouse SwissProt: Q811B3 Mouse Unigene: 481865 Human Unigene: 224825 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
整合素样金属蛋白酶与凝血酶1型-12抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid