中心体蛋白颁贰笔128抗体
规格：1尘驳/1尘濒
英文名： CEP164
别名： AI450905; BC027092; CE164_HUMAN; Centrosomal protein of 164 kDa; Cep164; CEP164; D030051D21; FLJ54767; KIAA1052; MGC38792; mKIAA1052; OTTMUSP00000042044; RGD1560988; RGD1561243.
分子量： 164kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CEP128
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆
中心体蛋白颁贰笔128抗体产物介绍：background: This gene encodes a centrosomal protein involved in microtubule organization, DNA damage response, and chromosome segregation. The encoded protein is required for assembly of primary cilia and localizes to mature centrioles. Defects in this gene are a cause of nephronophthisis-related ciliopathies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012] Function: Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA,CHK2 and CHK1.中心体蛋白颁贰笔128抗体 Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHK1. Subcellular Location: Cytoplasm; cytoskeleton; centrosome; centriole. Nucleus. Localizes specifically to very distally located appendage structures on the mature centriole from which initiate PC formation. Persisted at centrioles throughout mitosis. Expressed in中心体蛋白颁贰笔128抗体 chromatin-enriched nuclear fraction of HeLa cells. Tissue Specificity: Expressed in several cell lines. Post-translational modifications: Phosphorylation at Ser-186 is induced upon DNA-damage caused by treatment with IR irradiation, UV irradiation, hydroxyurea or amphidicolin. Also MDC1-mediated chromatin remodeling is critical for DNA damage-induced phosphorylation. Similarity: Contains 1 WW domain. Gene ID: 22897 Database links: Entrez Gene: 22897 Human Entrez Gene: 214552 Mouse Entrez Gene: 363055 Rat SwissProt: Q9UPV0 Human SwissProt: Q5DU05 Mouse Unigene: 504009 Human Unigene: 260103 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
中心体蛋白颁贰笔128抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid