自噬相关蛋白4叠抗体
规格：1尘驳/1尘濒
英文名： APG4B
别名： APG4B; ATG4 autophagy related 4 homolog B (S. cerevisiae); AUT like 1 cysteine endopeptidase; AUTL1; Autophagin 1; Autophagy related cysteine endopeptidase 1; Autophagy related protein 4 homolog B; Cy
分子量： 44kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human APG4B
交叉反应：Human, Mouse, Rat, Dog, Cow,
细胞定位：细胞浆
自噬相关蛋白4叠抗体产物介绍：background: Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Function: Cysteine protease required for autophagy, which cleaves the 自噬相关蛋白4叠抗体C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Subcellular Location: Cytoplasm (Probable). Tissue Specificity: Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas. Similarity: Belongs to the peptidase C54 family. Gene ID: 23192 Database 自噬相关蛋白4叠抗体links: Entrez Gene: 23192 Human Entrez Gene: 66615 Mouse Entrez Gene: 316640 Rat Omim: 611338 Human SwissProt: Q9Y4P1 Human SwissProt: Q8BGE6 Mouse SwissProt: Q62625 Rat Unigene: 283610 Human Unigene: 29087 Mouse Unigene: 163086 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 细胞自噬（Autophagy）是一种非凋亡性的程序性细胞死亡即自噬性程序性细胞死亡，进化过程中高度保守，**降解细胞内受损伤的细胞结构、衰老的细胞器、以及不再需要的生物大分子等，在细胞的生长、发育和**发生中起着重要的作用。细胞自噬是一个高效调控过程，特异性激酶和鸟嘌呤核苷酸磷酸酶（GTPases）在调节自噬通道活性中起着关键作用.
自噬相关蛋白4叠抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid