钙粘蛋白超家族颁贰尝厂搁1抗体
规格：1尘驳/1尘濒
英文名： CELSR1
别名： Cadherin EGF LAG seven pass G type receptor 1; Cadherin EGF LAG seven pass G type receptor; CDHF 9; CDHF9; CELS R1; CELSR 1; DKFZp434P0729; Flamingo homolog 2; Flamingo homolog; Flamingo homolog Droso
分子量： 327kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CELSR1
交叉反应：Human, Mouse, Rat, Chicken, Cow, Sheep,
细胞定位：细胞膜
钙粘蛋白超家族颁贰尝厂搁1抗体产物介绍：background: The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. [provided by RefSeq, Jul 2008] Function: Receptor that may have an important role in钙粘蛋白超家族颁贰尝厂搁1抗体 cell/cell signaling during nervous system formation. Subcellular Location: Integral membrane protein Post-translational modifications: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains (By similarity). DISEASE: Neural tube defects (NTD) [MIM:182940]: Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis钙粘蛋白超家族颁贰尝厂搁1抗体. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components. Note=The disease may be caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 9 cadherin domains. Contains 8 EGF-like domains. Contains 1 GPS domain. Contains 1 laminin EGF-like domain. Contains 2 laminin G-like domains. Gene ID: 9620 Database links: Entrez Gene: 9620 Human Omim: 604523 Human SwissProt: Q9NYQ6 Human Unigene: 252387 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
钙粘蛋白超家族颁贰尝厂搁1抗体产物应用：IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞膜受体 细胞粘附分子 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid