锌指转录因子厂濒耻驳抗体
规格：1尘驳/1尘濒
英文名： SNAI2
别名： SLUG; Neural crest transcription factor Slug; Protein snail homolog 2; Slug (chicken homolog) zinc finger protein; Slug homolog zinc finger protein; Slug zinc finger protein; SLUGH 1; SLUGH; SLUGH1; S
分子量： 30kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Slug
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit,
细胞定位：细胞核
锌指转录因子厂濒耻驳抗体产物介绍：background: This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]. Function: Transcriptional repressor. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occluding (OCLN) and subsequent oncogenic transformation of epithelial cells. Subunit: Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains). Subcellular Location: Nucleus. Cytoplasm. Note=Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap锌指转录因子厂濒耻驳抗体 with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions. Tissue Specificity: Expressed in most human tissues, including spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not detected in peripheral blood leukocyte. Expressed in the dermis and in all layers of the epidermis, with high levels of expression in the basal layers (at protein level). Expressed in osteoblasts (at protein level). Expressed in mesenchymal stem cells (at protein level). Expressed in breast tumor cells (at protein level). Post-translational modifications: GSK3B-mediated phosphorylation results in cytoplasmic localization and degradation. DISEASE: Defects in SNAI2 are the cause of Waardenburg syndrome type 2D 锌指转录因子厂濒耻驳抗体(WS2D) . WS2 is a genetically heterogeneous, autosomal dominant disorder characterized by sensorineural deafness, pigmentary disturbances, and absence of dystopia canthorum. The frequency of deafness is higher in WS2 than in WS1 Similarity: Belongs to the snail C2H2-type zinc-finger protein family. Contains 5 C2H2-type zinc fingers. Gene ID: 6591 Database links: Entrez Gene: 6591 Human Entrez Gene: 20583 Mouse Entrez Gene: 641345 Pig Entrez Gene: 25554 Rat Entrez Gene: 432368 Chicken Entrez Gene: 520631 Cow Omim: 602150 Human SwissProt: Q3MHQ4 Cow SwissProt: O43623 Human SwissProt: P97469 Mouse SwissProt: Q3UZ96 Mouse SwissProt: O08954 Rat Unigene: 360174 Human Unigene: 4272 Mouse Unigene: 43117 Rat Important Note: This product as 锌指转录因子厂濒耻驳抗体supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 转录调节因子（Transcriptin Regulators） 锌指转录因子Slug主要用于消化系统肿瘤转移方面的研究。
产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 神经生物学 信号转导 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid