去泛素酶16抗体
规格：1尘驳/1尘濒
英文名： USP16
别名： Deubiquitinating enzyme 16; Human ubiquitin processing protease; MSTP039; Ubiquitin carboxyl-terminal hydrolase 16; Ubiquitin Specific peptidase 16; Ubiquitin Specific Protease 16; Ubiquitin thioleste
分子量： 94kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human USP16
交叉反应：Human, Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核
去泛素酶16抗体产物介绍：background: This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Function: Specifically deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-10' of histone H3, and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A 去泛素酶16抗体deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. Subunit: Homotetramer. Subcellular Location: Nucleus. Tissue Specificity: Present in all the tissues examined including fetal brain, lung, liver, kidney, and heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Post-translational modifications: Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. The phosphorylated form of the protein is also enzymatically active. DISEASE: Note=A chromosomal aberration involving去泛素酶16抗体 USP16 is a cause of Chronic myelomonocytic leukemia. Inversion inv(21) (q21;q22) with RUNX1/AML1. Similarity: Belongs to the peptidase C19 family. USP16 subfamily. Contains 1 UBP-type zinc finger. Database links: Entrez Gene: 10600 Human GenBank: NM_006447 Human Omim: 604735 Human SwissProt: Q9Y5T5 Human Unigene: 99819 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
去泛素酶16抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 细胞分化 表观遗传学 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid