核顿狈础结合蛋白颁1顿抗体
规格：1尘驳/1尘濒
英文名： C1D
别名： 1110036E10Rik; AI875855; C1D; C1D DNA binding protein; C1D_HUMAN; hC1D; LRP1; MGC12261; MGC14659; MGC188504; Nuclear DNA binding protein; Nuclear nucleic acid binding protein C1D; Nuclear nucleic acid
分子量： 16kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human C1D
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Monkey,
细胞定位：细胞核 细胞浆
核顿狈础结合蛋白颁1顿抗体产物介绍：background: C1D, also known as SUNCOR, is a nuclear DNA-binding protein that localizes to the nucleus and cytoplasm and participates in processing of the 5.8S rRNA. Expressed ubiquitously with highest expression in thyroid, salivary gland, hippocampus and medulla oblongata, C1D forms a multi-protein complex with MPP6 (M phase phosphoprotein 6) and EXOSC10 (exosome component 10). This complex is responsible, in part, for recruiting the exosome to pre-rRNA and it functions to mediate 3’-5’ rRNA processing. Additionally, C1D can induce transcriptional repression and apoptosis through interaction with Rev-erbα (V-erbA-related protein EAR-1)/TRβ (thyroid hormone receptor β) and p53, respectively. C1D, a 141 amino acid protein, is also implicated in DNA repair mechanisms, as well as DNA-PK (DNA-dependent protein kinase) activation. Function: Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the核顿狈础结合蛋白颁1顿抗体 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB. Subcellular Location: Cytoplasm. Nucleus > nucleolus. EXOSC10 is required for nucleolar localization. Tissue Specificity: Ubiquitous. Expressed at very high levels in the hippocampus, medulla oblongata, mammary gland, thyroid and salivary gland.核顿狈础结合蛋白颁1顿抗体 Expressed at high levels in the fetal; lung, liver and kidney. Expressed at low levels in skeletal muscle, appendix, heart, lung and colon. Post-translational modifications: Phosphorylated by PRKDC. Similarity: Belongs to the C1D family. Gene ID: 10438 Database links: Entrez Gene: 10438 Human Entrez Gene: 506667 Cow Entrez Gene: 57316 Mouse Entrez Gene: 289810 Rat Omim: 606997 Human SwissProt: Q32PE4 Cow SwissProt: Q13901 Human SwissProt: O35473 Mouse Unigene: 87882 Cow Unigene: 602900 Human Unigene: 697447 Human Unigene: 287982 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
核顿狈础结合蛋白颁1顿抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 细胞凋亡 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid