颁顿244自然杀伤细胞受体2叠4抗体
规格：1尘驳/1尘濒
英文名： NKR2B4
别名： 2b4 cDNA 2B4; Cd244; CD244 natural killer cell receptor 2B4; Natural killer cell receptor 2B4; NK cell receptor 2B4; NKR2B4; CD244_HUMAN.
分子量： 39kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NKR2B4
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
颁顿244自然杀伤细胞受体2叠4抗体产物介绍：background: Natural killer (NK) cells are bone marrow-derived lymphocytes that can kill certain tumor cells and virally infected cells. There are multiple immunoglobulin superfamily (IgSF) receptor-ligand interactions that coordinate NK cell recognition of target cells and cytolytic function. The IgSF receptor NK 2B4 (CD244) is a ligand for CD48 that is expressed on the surface of all mouse and human NK cells and the subset of T cells that mediate NK-like killing. NK 2B4 is a cell surface glycoprotein of the immunoglobulin superfamily颁顿244自然杀伤细胞受体2叠4抗体 that is involved in the regulation of natural killer and T lymphocyte function. NK 2B4 binds the Src homology 2 domain-containing protein (SH2D1A) or signaling lymphocyte activation molecule (SLAM)-associated protein (SAP), which may function as regulators of NK 2B4-associated signal transduction pathways. NK 2B4 is expressed in human spleen, peripheral blood leukocytes, lymph node, bone marrow and fetal liver. Function: CD244 (2b4) is expressed on all human NK cells, a subpopulation of T cells, basophils and monocytes. CD244 activates颁顿244自然杀伤细胞受体2叠4抗体 NK cell mediated cytotoxicity, induces secretion of IFN-gamma and matrix metalloproteinases, and NK cell invasiveness. Although there have been several molecules shown to interact with CD244, the signaling mechanism ofCD244-mediated activation of NK cells is still unknown. It is a high affinity receptor for CD48. Subcellular Location: Cell Membrane; single-pass type I membrane protein Gene ID: 51744 Database links: Entrez Gene: 51744 Human Omim: 605554 Human SwissProt: Q9BZW8 Human Unigene: 157872 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
颁顿244自然杀伤细胞受体2叠4抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 自然杀伤细胞 t-**细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid