狈鲍顿颁顿3蛋白抗体
规格：1尘驳/1尘濒
英文名： NUDCD3
别名： KIAA1068; NudC domain containing 3; NudC domain containing protein 3; NudC like protein; NUDCD 3; NudCL; OTTHUMP00000159457; NUDC3_HUMAN; NudC domain-containing protein 3. .
分子量： 41kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NUDCD3
交叉反应：Human, Mouse, Rat, Pig,
细胞定位：细胞核
狈鲍顿颁顿3蛋白抗体产物介绍：background: Nuclear migration is essential for growth, development and cellular function of multicellular organisms. NUDCD3 (NudC domain containing 3) is a 361 amino acid protein that contains one CS domain and is phosphorylated upon DNA damage by either ATR or ATM. Ubiquitously expressed, NUDCD3 has been observed to colocalize with Golgi marker proteins during interphase of mitosis in HeLa cells, and is found at low levels in brain, ovary and heart. The gene encoding NUDCD3 maps to human chromosome 7, which houses over 狈鲍顿颁顿3蛋白抗体1,000 genes and comprises nearly 5% of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. Function: NUDCD3 functions to maintain the stability of dynein intermediate chain. Depletion of NUDCD3 results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from 狈鲍顿颁顿3蛋白抗体kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. NUDCD3 levels increase after the G1/S transition. Similarity: Contains 1 CS domain. Gene ID: 23386 Database links: Entrez Gene: 23386 Human Omim: 610296 Human SwissProt: Q8IVD9 Human Unigene: 488171 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
狈鲍顿颁顿3蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid