贰滨顿2蛋白抗体
规格：1尘驳/1尘濒
英文名： EID2
别名： CREBBP/EP300 inhibitor 2; CREBBP/EP300 inhibitory protein 2; CRI2; E1A like inhibitor of differentiation 2; EID-1-like inhibitor of differentiation 2; EID-2; EID2; EID2_HUMAN; EP300-interacting inhibi
分子量： 25kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human EID2
交叉反应：Human, Mouse, Rat, Pig, Cow, Sheep,
细胞定位：细胞核
贰滨顿2蛋白抗体产物介绍：background: As a regulator of transcription via chromatin remodeling, p300 is a histone acetyltransferase that binds to adenovirus E1A protein and may play a role in its transforming capacity. EID-2 (EP300-interacting inhibitor of differentiation 2), also known as CREBBP/EP300 inhibitor 2, is a 236 amino acid nuclear protein that cooperates with EID-2B to bind to the C-terminus of p300 to inhibit its activity. It also represses MYOD-dependent transcription and muscle differentiation. By interacting with SMAD2, SMAD3 and SMAD4, EID-2 selectively blocks the formation of TGFB-induced SMAD3-SMAD4 complex, thereby repressing TGFB/SMAD3-dependent signaling.贰滨顿2蛋白抗体 Though it is abundantly expressed in placenta, EID-2 is highly expressed in skeletal muscle, heart, liver, brain and kidney. There are two isoforms of EID-2 that are produced as a result of alternative splicing events. Function: Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 贰滨顿2蛋白抗体complex. Subcellular Location: Nucleus. Tissue Specificity: Most abundantly expressed in placenta. Highly expressed in liver, brain, heart, skeletal muscle, and kidney. Gene ID: 163126 Database links: Entrez Gene: 163126 Human Entrez Gene: 386655 Mouse Omim: 609773 Human SwissProt: Q8N6I1 Human SwissProt: Q6X7S9 Mouse Unigene: 18949 Human Unigene: 258201 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
贰滨顿2蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid