紧密粘连蛋白窜翱-3抗体
规格：1尘驳/1尘濒
英文名： Zonula occludens protein 3
别名： Tight junction protein 3; Tight junction protein ZO-3; Tight junction protein ZO3; TJP3; ZO3; ZO-3; ZO3_HUMAN; Zona occludens protein 3; Zonula occludens protein 3.
分子量： 103kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Zonula o
交叉反应：Human, Mouse, Rat, Horse,
细胞定位：细胞膜
紧密粘连蛋白窜翱-3抗体产物介绍：background: Tight junctions are complexes of proteins that create intercellular boundaries between the plasma membrane domains of epithelial and endothelial cells. Many of the tight junction-associated proteins are members of the membrane-associated guanylate kinase (MAGUK) family and include occludin, ZO-1, ZO-2 and ZO-3 (1,2). These proteins are thought to have both structural and signaling roles, and are characteristically defined by three protein-protein interaction modules: the PDZ domain, the SH3 domain and the guanylate kinase (GuK) domain (3). ZO-1 forms complexes with either ZO-2 or ZO-3 (4). In addition, these proteins can also associate with claudin,紧密粘连蛋白窜翱-3抗体 occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction (5-7). ZO-1 expression is significantly reduced in many breast cancer lines (8). ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue (2,3). Subcellular Location: Cell membrane. Cell junction; tight junction. Similarity: Belongs to the MAGUK family. Contains 1 guanylate kinase-like domain. Contains 3紧密粘连蛋白窜翱-3抗体 PDZ (DHR) domains. Contains 1 SH3 domain. Gene ID: 27134 Database links: Entrez Gene: 27134 Human Omim: 612689 Human SwissProt: O95049 Human Unigene: 25527 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
紧密粘连蛋白窜翱-3抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 细胞粘附分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid