钙粘蛋白相关蛋白颁罢狈狈础3抗体
规格：1尘驳/1尘濒
英文名： CTNNA3
别名： 4930429L08Rik; 4933408A16; Alpha catenin like protein; Alpha T catenin; Alpha T-catenin; Cadherin associated protein; Cadherin-associated protein; Catenin alpha 3; Catenin alpha-3; Catna3; CTNA3_HUMAN
分子量： 100kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CTNNA3
交叉反应：Human, Mouse, Rat, Dog, Horse, Rabbit,
细胞定位：细胞膜
钙粘蛋白相关蛋白颁罢狈狈础3抗体产物介绍：background: The catenins are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. alpha T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantally expressed in cardiomyocytes and in the peritubular myoid cells of the testis. alpha T-catenin binds to alpha E-catenin as well as to beta-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for alpha-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer's disease (LOAD) as well as to 钙粘蛋白相关蛋白颁罢狈狈础3抗体dilated cardiomyopathy. Function: May be involved in formation of stretch-resistant cell-cell adhesion complexes. Subcellular Location: Cytoplasm; cytoskeleton. Localizes to intercalated disks of cardiomyocytes and in peritubular myoid cells of testis, and colocalizes with CTNNA1 and CTNNA2. Tissue Specificity: Predominantly expressed in heart and testis. Expressed at lower levels in brain, kidney, 钙粘蛋白相关蛋白颁罢狈狈础3抗体liver and skeletal muscle. Similarity: Belongs to the vinculin/alpha-catenin family. Gene ID: 29110 Database links: Entrez Gene: 29110 Human Entrez Gene: 29119 Human Entrez Gene: 216033 Mouse Entrez Gene: 361839 Rat Omim: 607667 Human SwissProt: Q9UHD2 Human SwissProt: Q9UI47 Human SwissProt: Q65CL1 Mouse Unigene: 660362 Human Unigene: 444692 Mouse Unigene: 223553 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
钙粘蛋白相关蛋白颁罢狈狈础3抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞粘附分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid