肾小管间质肾炎抗原抗体
规格：1尘驳/1尘濒
英文名： TIN-Ag
别名： TINAG; TIN AG; TIN-Ag; TIN1; TIN2; TINAG; TINAG_HUMAN; Tubulointerstitial nephritis antigen.
分子量： 55kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TIN-Ag
交叉反应：Human, Mouse, Rat, Cow, Horse, Sheep,
细胞定位：细胞浆
肾小管间质肾炎抗原抗体产物介绍：background: Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein. Function: Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein. Subcellular Location: Secreted; extracellular space; extracellular matrix; basement membrane. Tissue Specificity: Expressed in the kidney cortex, small intestine and cornea. Post-translational modifications:肾小管间质肾炎抗原抗体 It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus 2 alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both. DISEASE: Initially observed in the Bowman capsule during early glomerular capillary loop formation in the kidney. In more developmentally mature glomeruli, following transition from肾小管间质肾炎抗原抗体 early to mid-capillary loop stage, expression is higher in the proximal tubular basement membrane than in the distal basement membrane and Bowman capsule. Similarity: Belongs to the peptidase C1 family. Contains 1 SMB (somatomedin-B) domain. Database links: Entrez Gene: 27283 Human Omim: 606749 Human SwissProt: Q9UJW2 Human Unigene: 127011 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 肾小管间质性肾炎抗原(tubulointerstitial nephritis antigen,TINag)是一种主要表达在肾脏近曲小管基底膜,少部分表达在远端小管和鲍曼囊以及肠黏膜基底膜的膜糖蛋白,TINag与Ⅳ型胶原蛋白和层粘连蛋白等细胞外基质具有较高的亲和力,对维持小管基底膜的结构与功能具有重要作用.
肾小管间质肾炎抗原抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid