丝裂原活化蛋白激酶相互作用蛋白1抗体
规格：1尘驳/1尘濒
英文名： MAP2K1IP1
别名： LAMTOR3; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3; LTOR3_HUMAN; MAP2K1IP1; MEK binding partner 1; MEK partner 1; MEK-binding partner 1; Mitogen activated protein kinase kinase 1
分子量： 13.6kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MAP2K1IP
交叉反应：Human, Mouse, Rat, Chicken, Cow, Zebrafish,
细胞定位：细胞膜
丝裂原活化蛋白激酶相互作用蛋白1抗体产物介绍：background: This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 丝裂原活化蛋白激酶相互作用蛋白1抗体2011] Function: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that 丝裂原活化蛋白激酶相互作用蛋白1抗体enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. Subcellular Location: Late endosome membrane. Similarity: Belongs to the LAMTOR3 family. Database links: Entrez Gene: 8649 Human Entrez Gene: 56692 Mouse Entrez Gene: 362045 Rat Entrez Gene: 553597 Zebrafish Omim: 603296 Human SwissProt: Q9UHA4 Human SwissProt: O88653 Mouse SwissProt: Q5U204 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
丝裂原活化蛋白激酶相互作用蛋白1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid