鲍叠齿狈2叠蛋白抗体
规格：1尘驳/1尘濒
英文名： UBXN2B
别名： NSFL1 cofactor p37; p37; p97 cofactor p37; UBX domain containing protein 2B; UBX domain protein 2B; UBX domain-containing protein 2B; UBX2B_HUMAN; UBXN2B
分子量： 37kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human UBXN2B
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
细胞定位：细胞核 细胞浆
鲍叠齿狈2叠蛋白抗体产物介绍：background: The UBX (Ubiquitin regulatory X) domain is an 80 amino acid motif that is usually present on the carboxy-terminus of certain eukaryotic proteins. UBX domain-containing proteins (UBXD), such as FAF1, p33ING1 and D8S2298E, are typically involved in ubiquitin-related processes. UBXD proteins also constitute the largest family of VCP cofactors and are generally involved in substrate recruitment to VCP, as well as regulation of its activity. UBXD2B (UBX domain-containing protein 2B), also known as NSFL1 cofactor p37 鲍叠齿狈2叠蛋白抗体and p97 cofactor p37, is a 331 amino acid protein that contains one UBX domain and one SEP domain. UBXN2B is required for ER and Golgi biogenesis and also plays a role in their maintenance during interphase, as well as their reassembly at the end of mitosis. Through interaction with VCP, UBXN2B forms a complex that has membrane fusion activity. Function: Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with鲍叠齿狈2叠蛋白抗体 VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity. Subunit: Interacts with VCP. Does not bind ubiquitin (By similarity). Subcellular Location: Nucleus. Cytoplasm; cytosol. Endoplasmic reticulum. Golgi apparatus. Similarity: Belongs to the NSFL1C family. Contains 1 SEP domain. Contains 1 UBX domain. Database links: Entrez Gene: 137886 Human Omim: 610686 Human SwissProt: Q14CS0 Human Unigene: 155572 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
鲍叠齿狈2叠蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid