丝裂原活化蛋白激酶相互作用蛋白3抗体
规格：1尘驳/1尘濒
英文名： JIP3
别名： C-jun-amino-terminal kinase-interacting protein 3; FLJ00027; Homolog of Drosophila Sunday driver 2; JIP-3; JIP3_HUMAN; JNK / Stress Activated Protein Kinase Associated Protein 1; JNK Interacting Prote
分子量： 147kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human JIP3
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep,
细胞定位：细胞浆
丝裂原活化蛋白激酶相互作用蛋白3抗体产物介绍：background: The JNK-interacting proteins (JIPs) are a family of scaffold proteins that mediate JNK signaling by organizing specific components of the MAPK cascade together to form a functional JNK signaling molecule. JIP-3 (JNK-interacting protein 3), also known as JSAP1 or MAPK8IP3 (Mitogen-activated protein kinase 8-interacting protein 3), is a 1,336 amino acid protein that localizes to the cytoplasm and belongs to the JIP family. Expressed in a variety of tissues, including brain and heart, JIP-3 forms homo- or heterooligomeric complexes that can interact with several components of the JNK signaling pathway, thereby functioning as a regulator of kinesin-dependent axonal transport that may also play a role in scaffold formation within neuronal cells. Human JIP-3, which may be phosphorylated upon DNA 丝裂原活化蛋白激酶相互作用蛋白3抗体damage, shares 69% similarity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of JIP-3 exist due to alternative splicing events. Function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a丝裂原活化蛋白激酶相互作用蛋白3抗体 regulator of vesicle transport, through interations Subcellular Location: Cytoplasm. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the JIP scaffold family. Database links: Entrez Gene: 23162 Human Entrez Gene: 30957 Mouse Omim: 605431 Human SwissProt: Q9UPT6 Human SwissProt: Q9ESN9 Mouse Unigene: 207763 Human Unigene: 43081 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
丝裂原活化蛋白激酶相互作用蛋白3抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 神经生物学 信号转导 激酶和磷酸酶 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid