贬厂贬2顿抗体
规格：1尘驳/1尘濒
英文名： HSH2D
别名： Adaptor in lymphocytes of unknown function X; ALX; FLJ14886; hematopoietic SH2 domain containing; Hematopoietic SH2 domain containing protein; Hematopoietic SH2 domain-containing protein; Hematopoieti
分子量： 39kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HSH2D
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
细胞定位：细胞核 细胞浆
贬厂贬2顿抗体产物介绍：background: HSH2 is a 352 amino acid nuclear and cytoplasmic protein that is predominantly expressed in spleen and hematopoietic cells, such as peripheral blood leukocytes, and weakly expressed in prostate, thymus, heart, small intestine and placenta. Containing an SH2 domain, four PXXP polyproline sequences and two possible tyrosine phosphorylation sites, HSH2 interacts with tyrosine kinases Fes and ACK. Considered an adaptor protein, HSH2 participates in tyrosine kinase signaling and may be involved in the regulation of 贬厂贬2顿抗体cytokine signaling and cytoskeletal reorganization in hematopoietic cells. HSH2 may also act to attenuate apoptosis through modulating the apoptotic response by promoting mitochondrial stability. HSH2 exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 19p13.11. Function: May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 贬厂贬2顿抗体promoter. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Predominantly expressed in spleen and hematopoietic cells such as peripheral blood leukocytes and weakly expressed in prostate, thymus, heart, small intestine and placenta. Post-translational modifications: May be phosphorylated by FES and ACK1. Similarity: Contains 1 SH2 domain. Gene ID: 84941 Database links: Entrez Gene: 84941 Human Omim: 608349 Human SwissProt: Q96JZ2 Human Unigene: 631617 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
贬厂贬2顿抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid