生长因子受体结合蛋白2相关接头蛋白抗体
规格：1尘驳/1尘濒
英文名： GRAP
别名： Grap; GRAP_HUMAN; GRB2 related adaptor protein; GRB2-related adapter protein; Growth factor receptor bound protein 2 related adaptor protein; MGC64880; OTTHUMP00000065766.
分子量： 25kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GRAP
交叉反应：Human, Mouse, Rat, Cow, Horse, Rabbit,
细胞定位：细胞膜
生长因子受体结合蛋白2相关接头蛋白抗体产物介绍：background: Many growth factors function by binding receptors with intrinsic tyrosine kinase activity. Signaling by such receptors involves a series of intermediates characterized by SH2 domains that bind tyrosine phosphorylated receptors by a direct interaction between the SH2 domain and specific receptor sequences. For instance, the GRB family of proteins lack a defined catalytic activity and are entirely composed of SH2 and SH3 domains. Members include GRB2, GRB7, GRB10 (also referred to as GRB-IR), GRB14 and Grap (for GRB2-related adapter protein). While GRB10 and GRB14 are most closely related to GRB7, Grap shares the highest degree生长因子受体结合蛋白2相关接头蛋白抗体 of homology with GRB2 exhibiting 59% sequence identity with GRB2. The Grap SH2 domain is capable of binding to the activated stem cell factor receptor, c-Kit and the erythropoietin receptor (EpoR). Grap also associates with the Ras guanine nucleotide exchange factor Sos 1 via its amino terminal SH3 domain. Function: Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Subunit: Associates through its SH2 domain with ligand-activated receptors for stem cell factor (KIT) and erythropoietin (EPOR).生长因子受体结合蛋白2相关接头蛋白抗体 Also forms a stable complex with the Bcr-Abl oncoprotein. GRAP is associated with the Ras guanine nucleotide exchange factor SOS1, primarily through its N-terminal SH3 domain. Interacts with phosphorylated LAT upon TCR activation. Interacts with SHB. Similarity: Belongs to the GRB2/sem-5/DRK family. Contains 1 SH2 domain. Contains 2 SH3 domains. Contains 1 SH2 domain. Contains 2 SH3 domains. Gene ID: 10750 Database links: Entrez Gene: 10750 Human Entrez Gene: 71520 Mouse Omim: 604330 Human SwissProt: Q13588 Human SwissProt: Q9CX99 Mouse Unigene: 567416 Human Unigene: 202760 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
生长因子受体结合蛋白2相关接头蛋白抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 生长因子和** 激酶和磷酸酶 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid