生长抑制顿狈础损伤基因45抗体
规格：1尘驳/1尘濒
英文名： GADD45
别名： GA45B_HUMAN; GADD45 Beta; Gadd45b; GADD45BETA; Growth arrest and DNA damage inducible 45 beta; Growth arrest and DNA damage inducible beta; Growth arrest and DNA damage-inducible protein GADD45 beta;
分子量： 18kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GADD45
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow,
细胞定位：细胞浆 细胞膜
生长抑制顿狈础损伤基因45抗体产物介绍：background: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53 dependent and independent mechanisms. Function: In T-cells, functions as a regulator of p38 MAPKs by 生长抑制顿狈础损伤基因45抗体inhibiting p88 phosphorylation and activity. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. Subunit: Interacts with MAPK14. Predominantly monomeric but also forms dimers and other oligomers as concentration increases. Interacts with GADD45GIP1. Interacts weakly with PCNA. Interacts with生长抑制顿狈础损伤基因45抗体 AURKA, likely to compete with dimerization. Subcellular Location: Nucleus. Similarity: Belongs to the GADD45 family. Gene ID: 4616 Database links: Entrez Gene: 4616 Human Entrez Gene: 17873 Mouse Entrez Gene: 299626 Rat Omim: 604948 Human SwissProt: O75293 Human SwissProt: P22339 Mouse Unigene: 110571 Human Unigene: 1360 Mouse Unigene: 35886 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. GADD45α蛋白与细胞凋亡和死亡密切相关,在某种程度上决定了细胞周期的进程。
生长抑制顿狈础损伤基因45抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 信号转导 细胞凋亡 细胞周期蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid