阳离子通道精子相关蛋白β亚基抗体
规格：1尘驳/1尘濒
英文名： CATSPERB
别名： C14orf161; Cation channel sperm-associated protein subunit beta; Cation channel, sperm-associated, beta; Catsper channel auxiliary subunit beta; CatSper(beta); CATSPERB; FLJ14298; CTSRB_HUMAN.
分子量： 127kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CATSPERB
交叉反应：Human, Mouse, Rat, Dog,
细胞定位：细胞膜
阳离子通道精子相关蛋白β亚基抗体产物介绍：background: CatSpers are ion transport proteins located on the surface of sperm cells in the principal piece of the sperm tail. CatSpers are vital to sperm motility, fertilization and cAMP-mediated calcium influx in sperm. There are four CatSper proteins in mammalian sperm, namely CatSper (or CatSper1), CatSper2, CatSper3 and CatSper4. CatSper proteins are believed to assemble into a heterotetrameric complex, forming an alkalinization-activated Ca2+-selective channel. CatSper∫ is a multipass membrane protein that functions as an auxiliary protein of the CatSper channel. It contains a large extracellular domain and a number of N-glycosylation sites. CatSper∫阳离子通道精子相关蛋白β亚基抗体 specifically interacts with CatSper1 and through this interaction plays an important role in the hyperactivated motility of sperm cells, a process that is required in the preparation of sperm for fertilization. Function: RelevanceCATSPERB is a component of a complex composed at least of CATSPER1, CATSPERB, CATSPERG and HSPA1B. CATSPERB contains at least 2 transmembrane domains and 8 N-glycosylation sites. CATSPERB is required for trafficking or formation of a stable channel complex. It is involved in sperm cell hyperactivation via its association with阳离子通道精子相关蛋白β亚基抗体 CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. There are 2 isoforms produced by alternative splicing. Subcellular Location: Membrane; Multi-pass membrane protein Gene ID: 79820 Database links: Entrez Gene: 79820 Human Omim: 611169 Human SwissProt: Q9H7T0 Human Unigene: 131755 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
阳离子通道精子相关蛋白β亚基抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 发育生物学 干细胞 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid