锌指蛋白198抗体
规格：1尘驳/1尘濒
英文名： ZMYM2
别名： FIM; Fused in myeloproliferative disorders protein; MYM; RAMP; Rearranged in atypical myeloproliferative disorder protein; SCLL; ZFP 198; Zinc finger MYM type protein 2; Zinc finger MYM-type protein 2
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ZMYM2/ZN
交叉反应：Human, Mouse, Rat, Rabbit,
细胞定位：细胞核
锌指蛋白198抗体产物介绍：background: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF198 (zinc finger 198), also known as ZMYM2 (zinc finger, MYM-type 2), FIM, MYM, RAMP or SCLL, is a 1,377 amino acid protein that localizes to the nucleus and contains nine MYM-type zinc fingers. Thought to be a component of the BHC histone deacetylase complex, ZNF198 interacts with HDAC1 and HDAC2 and is thought to stabilize the BHC complex via its MYM-type zinc fingers. The gene encoding ZNF198 is subject to a translocation with Flg, an event that may be involved in the锌指蛋白198抗体 pathogenesis of stem cell leukemia lymphoma syndrome (SCLL), a lymphoblastic lymphoma often accompanied by pronounced peripheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow. Function: May function as a transcription factor. Subcellular Location: Nucleus. DISEASE: Note=A chromosomal aberration involving ZMYM2 may be a cause of stem cell leukemia lymphoma syndrome锌指蛋白198抗体 (SCLL). Translocation t(8;13)(p11;q12) with FGFR1. SCLL usually presents as lymphoblastic lymphoma in association with a myeloproliferative disorder, often accompanied by pronounced peripheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow. Similarity: Contains 9 MYM-type zinc fingers. Gene ID: 7750 Database links: Entrez Gene: 7750 Human Entrez Gene: 76007 Mouse Omim: 602221 Human SwissProt: Q9UBW7 Human SwissProt: Q9CU65 Mouse Unigene: 507433 Human Unigene: 31417 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
锌指蛋白198抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 干细胞 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid
分子量： 160kDa