同源结构域转录因子贬贰厂齿1抗体
规格：1尘驳/1尘濒
英文名： HESX1
别名： HESX1_HUMAN; Homeobox expressed in ES cells 1; Homeobox protein ANF; hAnf.
分子量： 21kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HESX1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核
同源结构域转录因子贬贰厂齿1抗体产物介绍：background: The homeobox protein, HESX1, which is also known as Rathke’s pouch homeobox, HANF, homeodomain transcription factor, and anterior-restricted homeobox protein is a transcription factor that belongs to the homeodomain family of DNA binding proteins. HESX1 is initially expressed in embryonic stem cells and the primitive forebrain, and is essential for normal development of the eyes and other anterior CNS structures, such as the hypothalamus, the pituitary gland and the olfactory bulbs. The homeobox gene Hesx1 is expressed in the anterior visceral endoderm (AVE), anterior axial mesendoderm (AME), and anterior neural ectoderm (ANE) during early embryogenesis. Mutations in the Hesx1 gene are associated with disorders that are comparable with septo-optic dysplasia (SOD). These disorders are characterized by hypoplasia of the optic nerve, various types of forebrain defects and pituitary hormone deficiencies, including hypothyroidism.同源结构域转录因子贬贰厂齿1抗体 Hesx1 also acts as a transcriptional repressor of reporter gene constructs in tissue culture assays. Function: Homeobox protein expressed in embryonic stem cells and targetd by Sox2, Oct4 and Nanog. Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Subunit: Can form heterodimers with PROP1 in binding to DNA. Interacts with TLE1. Subcellular Location: Nuclear DISEASE: Septooptic dysplasia (SOD) [MIM:182230]: A clinically heterogeneous disorder defined by any combination of optic nerve hypoplasia, pituitary gland hypoplasia with panhypopopituitarism, and midline abnormalities of the brain, including absence of the corpus callosum and septum pellucidum. Note=The disease is caused by mutations affecting the gene represented in this entry. Growth hormone deficiency with pituitary anomalies (GHDPA) [MIM:182230]: A disease characterized by low or absent growth hormone同源结构域转录因子贬贰厂齿1抗体 levels, in the presence of a hypoplastic anterior pituitary lobe and ectopic or absent posterior pituitary lobe. Note=The disease is caused by mutations affecting the gene represented in this entry. Pituitary hormone deficiency, combined, 5 (CPHD5) [MIM:182230]: Combined pituitary hormone deficiency is defined as the impaired production of growth hormone and one or more of the other five anterior pituitary hormones. CPHD5 is characterized by complete or partial deficiencies of growth hormone, thyroid-stimulating hormone, luteinizing hormone, follicle stimulating hormone and adrenocorticotropic hormone. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the ANF homeobox family. Contains 1 homeobox DNA-binding domain. Gene ID: 8820 Database links: Entrez Gene: 8820 Human Omim: 601802 Human SwissProt: Q52LC5 Human SwissProt: Q9UBX0 Human Unigene: 171980 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
同源结构域转录因子贬贰厂齿1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 神经生物学 干细胞 转录调节因子 细胞粘附分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid