骋蛋白偶联受体3抗体
规格：1尘驳/1尘濒
英文名： GPR3
别名： ACCA; ACCA orphan receptor; Adenylate cyclase constitutive activator; G protein coupled receptor 3; G-protein coupled receptor 3; Gpr3; GPR3_HUMAN; Probable G protein coupled receptor GPR3; GPCR GPR3.
分子量： 35kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human G-protei
交叉反应：Human, Dog,
细胞定位：细胞膜
骋蛋白偶联受体3抗体产物介绍：background: G protein-coupled receptor 3 (GPR3), also designated ACCA orphan receptor, is a 330 amino acid member of the G protein-coupled receptor 1 family. The function of GPR3 is mediated by G proteins which activate adenylate cyclase. GPR3 is a mutli-pass membrane protein that is located on the cellular membrane of cells and is detected at low levels in the eye, kidney, lung, ovary and testis. GPR3 is most highly expressed in the central nervous system, where it stimulates the production of cAMP, leading to neurite outgrowth and myelin inhibition. In oocytes, this control over cAMP production can halt meiosis and prevent progesterone-induced meiotic maturation骋蛋白偶联受体3抗体. Mice deficient for GPR3 are able to reproduce but have no control over the oocyte maturation process, which results in nondeveloping early embryos and fragmented oocytes as the mice age. Function: Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes. Subcellular Location: Cell membrane. Tissue Specificity:骋蛋白偶联受体3抗体 Expressed predominantly in the central nervous system, and at low levels in the lung, kidney, testis, ovary and eye. Highly expressed in regions of the brain implicated in the Alzheimer disease. Similarity: Belongs to the G-protein coupled receptor 1 family. Gene ID: 2827 Database links: Entrez Gene: 2827 Human Omim: 600241 Human SwissProt: P46089 Human Unigene: 66542 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
骋蛋白偶联受体3抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid