高尔基体磷蛋白6抗体
规格：1尘驳/1尘濒
英文名： GORASP2
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GORASP2/
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, Xenopus laevis
细胞定位：细胞浆 细胞膜
高尔基体磷蛋白6抗体产物介绍：background: The Golgi apparatus is a highly complex organelle comprised of a stack of cisternal membranes on the secretory pathway from the ER to the cell surface. The structure is maintained by an exoskeleton or Golgi matrix constructed from a family of coiled-coil protein, the golgins and other peripheral membrane components such as GRASP55 and GRASP65 (1). GRASP55 (Golgi reassembly stacking protien or p59) is a component of the Golgi stacking machinery. GRASP55 is highly homologous to GRASP65 and contains two PDZ domains. GRASP55 is myristoylated and palmitoylated. Unlike GRASP65, GRASP55 does not have detectable binding with the vesicle docking protein GM130 and is located on the medial-Golgi rather than cis-Golgi. Both GRASP55 and GRASP65 function in the stacking of Golgi Cisternae (2,3). The novel coiled-coil protein golgin 45 interacts with GRASP55 and the GTP form of Rab 2, suggesting that GRASP55 and golgin 45 form a Rab 2 effector complex on medial-Golgi essential for normal protein transport and Golgi structure (4). ERK2 directly phosphorylates GRASP55, which is phosphorylated in mitotic cells, suggesting that mitogen-activated protein kinase kinase (MKK)/ERK pathway phosphorylates the Golgi during mitosis (5). Function: May高尔基体磷蛋白6抗体 be involved in assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after mitotic breakdown. May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA. Subcellular Location: Golgi apparatus membrane. Post-translational modifications: Myristoylated. Myristoylation is essential for the Golgi targeting. Palmitoylated. Phosphorylated in mitotic cells. Similarity: Belongs to the GORASP family. Contains 1 PDZ (DHR) domain. Database links: Entrez高尔基体磷蛋白6抗体 Gene: 26003 Human Entrez Gene: 70231 Mouse Omim: 608693 Human SwissProt: Q9H8Y8 Human SwissProt: Q99JX3 Mouse Unigene: 431317 Human Unigene: 271950 Mouse Unigene: 470827 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 转运蛋白 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
高尔基体磷蛋白6抗体来源： Rabbit
外观： Lyophilized or Liquid
别名： AW552058; DKFZp434D156; FLJ13139; Golgi phosphoprotein 6; Golgi reassembly stacking protein 2; Golgi reassembly stacking protein 2, 55kDa; Golgi reassembly stacking protein of 55 kDa; Golgi reassembly
分子量： 47kDa