糖皮质**调节元件结合蛋白1抗体
规格：1尘驳/1尘濒
英文名： GMEB1
别名： DNA binding protein p96PIF; DNA-binding protein p96PIF; Glucocorticoid modulatory element binding protein 1; Glucocorticoid modulatory element-binding protein 1; GMEB 1; GMEB-1; Gmeb1; GMEB1_HUMAN; P9
分子量： 63kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GMEB1
交叉反应：Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
糖皮质**调节元件结合蛋白1抗体产物介绍：background: GMEB-1 is a 573 amino acid protein that contains one SAND domain and is a member of the KDWK family of combinatorial transcription modulators. Localized to both the cytoplasm and the nucleus, GMEB-1 forms a heterodimer with GMEB-2 (Glucocorticoid modulatory element-binding protein 2) and, once associated with GMEB-2, plays a key role in parvovirus DNA replication. In addition, GMEB-1 functions alone as a trans-acting factor that, by binding to glucocorticoid modulatory elements (GMEs) in TAT (tyrosine aminotransferase) promoters, increases intracellular sensitivity to glucocorticoid concentrations. GMEB-1 also interacts with initiator procaspases and, via this interaction, can inhibit caspase-induced apoptosis. Due to alternative splicing events, GMEB-1 is expressed as two isoforms.糖皮质**调节元件结合蛋白1抗体 Function: Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses. Subunit: Homodimer, and heterodimer of GMEB1 and GMEB2. GMEB1 and糖皮质**调节元件结合蛋白1抗体 GMEB2 form the parvovirus initiator complex (PIF). Interacts with the glucocorticoid receptor (NR3C1) and NCOA2/TIF2 (By similarity). May interact with HSP27 and CREB-binding protein (CBP). Subcellular Location: Nucleus. Cytoplasm. May be also cytoplasmic. Similarity: Contains 1 SAND domain. Database links: UniProtKB/Swiss-Prot: Q9Y692.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
糖皮质**调节元件结合蛋白1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 结合蛋白 新陈代谢 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid