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糖原蛋白1

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产物名称: 糖原蛋白1
产物型号: Glycogenin 1
产物展商: 单克隆抗体/多克隆抗体
产物文档: 无相关文档

简单介绍

糖原蛋白1应用于IHC、WB、 IF、IP、ELISA等科研实验,按理化性质和生物学功能IgM、IgG、IgA、IgE、IgD五类。按抗体的来源,可将其分为天然抗体和**抗体。糖原蛋白1生产每个流程都执行严格的检测标准,保证蛋白抗原产物质量,质量稳定,实验效果明显。


糖原蛋白1  的详细介绍

糖原蛋白1

规格:1尘驳/1尘濒

英文名: Glycogenin 1

别名: Glycogenin; Glycogenin-1; Glycogenin1; GLYG_HUMAN; GN-1; GN1; GYG 1; GYG; GYG1.

分子量: 39kDa

储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型:笔辞濒测肠濒辞苍补濒

亚型:滨驳骋

纯化方法:affinity purified by Protein A

**原:KLH conjugated synthetic peptide derived from human Glycogen

交叉反应:Human, Mouse, Rat, Dog, Cow, Sheep,

细胞定位:

糖原蛋白1产物介绍:background: Glycogen synthesis is initiated by the autoglucosylation of Glycogenin-1. Specifically, Glycogenin-1 glucosylates itself to begin the synthesis of glycogen in mammalian skeletal muscle. It acts as the primer to which further glucose monomers may be added. All of the Glycogenin-1 molecules contain at least one glucosyl residue before autoglucosylation begins. The first step of the glycogen synthesis occurs when a glucose molecule from UDP-glucose binds to the hydroxyl group of Tyr 194 on the Glycogenin-1 molecule. Using its glucosyltransferase activity, Glycogenin-1 adds more glucoses, each one coming from UDP-glucose. The glycosylation process reaches 糖原蛋白1a plateau when five new glucose residues have been added, at which point glycogen synthase (GS) takes over and further elongates the chain. Glycogenin-1 remains covalently attached to the reducing end of the glycogen molecule. Function: Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase. Subunit: Homodimer tightly complexed to the 86 kDa catalytic subunit of glycogen synthase GYS1. Post-translational modifications: Self-glycosylated by the transfer of glucose residues from UDP-glucose to itself,糖原蛋白1 forming an alpha-1,4-glycan of around 10 residues attached to Tyr-195. Phosphorylated. DISEASE: Defects in GYG1 are the cause of glycogen storage disease type 15 (GSD15) [MIM:613507]. It is a metabolic disorder resulting in muscle weakness, associated with the glycogen depletion in skeletal muscle, and cardiac arrhythmia, associated with the accumulation of abnormal storage material in the heart. The skeletal muscle shows a marked predominance of slow-twitch, oxidative muscle fibers and mitochondrial proliferation. Similarity: Belongs to the glycogenin family. Gene ID: 2992 Database links: Entrez Gene: 2992 Human Omim: 603942 Human SwissProt: P46976 Human Unigene: 477892 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

糖原蛋白1产物应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域:肿瘤  细胞生物  信号转导  糖蛋白  新陈代谢  

储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源: Rabbit

外观: Lyophilized or Liquid


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