葡萄糖苷酶2β/Glucosidase IIβ抗体
规格：1尘驳/1尘濒
英文名： Glucosidase 2 subunit beta
别名： 80K-H protein; AGE-binding receptor 2; AGE-R2; G19P1; GLU2B_HUMAN; Glucosidase 2 subunit beta; Glucosidase II beta subunit; Glucosidase II subunit beta; Hepatocystin; PCLD; PKCSH; PLD1; PRKCSH; Protei
分子量： 58kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Glucosid
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse,
细胞定位：细胞浆
葡萄糖苷酶2β/Glucosidase IIβ抗体产物介绍：background: Trimming of glucoses from N-linked core glycans on newly synthesized glycoproteins occurs sequentially through the action of Glucosidases I and II in the endoplasmic reticulum (ER). Glucosidase II is an ER-localized enzyme that contains a and b subunits (Glucosidase IIa and Glucosidase IIb) which form a defined heterodimeric complex. Glucosidase IIa is the catalyitc core of the enzyme and can function independently of the b subunit. The sequence of Glucosidase IIb encodes protein rich in glutamic and aspartic acid with a putative ER retention signal (HDEL) at the C-terminus. The phosphorylated form of Glucosidase IIb is localized in the葡萄糖苷酶2β/Glucosidase IIβ抗体 plasma membrane and is highly expressed in FGF-stimulated fibroblasts and epidermal carcinoma cells. Glucosidase IIb was first purified from a human carcinoma cell line as a potential substrate for protein kinase C. Through the HDEL signal at the C-terminus, Glucosidase IIb retains the complete complex in the ER. Function: Regulatory subunit of glucosidase II. Subunit: Heterodimer of a catalytic alpha subunit (GANAB) and abeta subunit (PRKCSH). Binds glycosylated PTPRC (By similarity). Subcellular Location: Endoplasmic reticulum. DISEASE: Defects in PRKCSH葡萄糖苷酶2β/Glucosidase IIβ抗体 are a cause of polycystic liver disease (PCLD) [MIM:174050]. PCLD is an autosomal dominant disorder and is characterized by the presence of multiple liver cysts of biliary epithelial origin. PCLD is a distinct clinical and genetic entity that can occur independently from autosomal dominant polycystic kidney disease (ADPKD) [MIM:173900], which in a considerable but uncertain proportion of cases is associated with hepatic cysts. Similarity: Contains 2 EF-hand domains. Contains 1 PRKCSH domain. Database links: UniProtKB/Swiss-Prot: P14314.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
葡萄糖苷酶2β/Glucosidase IIβ抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid