染色体卷曲螺旋域包含蛋白1抗体
规格：1尘驳/1尘濒
英文名： GEMC1
别名： GEMC1; Geminin coiled coil domain containing protein 1; Gm606; GEMC1_HUMAN.
分子量： 38kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：笔辞濒测肠濒辞苍补濒
亚型：滨驳骋
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GEMC1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核
染色体卷曲螺旋域包含蛋白1抗体产物介绍：background: GEMC1 is a 334 amino acid nuclear protein that regulates DNA replication by promoting the recruitment of Cdc45 onto replication origins. A member of the GEMC1 family, GEMC1 is highly phosphorylated and interacts with chromatin during formation of the pre-replication complex. The gene encoding GEMC1 maps to human chromosome 3, which is made up of about 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human染色体卷曲螺旋域包含蛋白1抗体 cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease 染色体卷曲螺旋域包含蛋白1抗体are a few of the numerous genetic diseases associated with chromosome 3. Function: Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2-dependent recruitment of CDC45L onto replication origins. Subcellular Location: Nucleus (By similarity). Note=Associates with chromatin during pre-replication complex (pre-RC) formation (By similarity). Post-translational modifications: Highly phosphorylated by CDK2; stimulates initiation of DNA replication (By similarity). Similarity: Belongs to the GEMC1 family. Database links: UniProtKB/Swiss-Prot: A6NCL1.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
染色体卷曲螺旋域包含蛋白1抗体产物应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 神经生物学 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid